Modern materials research and manufacturing quality control laboratories are increasingly faced with the need to obtain complex data on the raw materials under investigation. Traditional particle size measurement methods often do not provide the full picture, especially when it comes to particle morphology. Particle shape has a direct impact on the quality of the final product, flowability, powder compaction, solubility or even chemical reactivity. This is why the Bettersizer S3 Plus stands out on the market as a revolutionary analytical solution that combines two powerful technologies – laser diffraction and dynamic image analysis – into a single, seamless and fully automated research platform.
Innovative laser diffraction optical system
The basis of the device's operation is the unique, manufacturer-patented DLOI (Dual Lenses & Oblique Incidence) optical technology. Unlike standard systems that use only one lens and often face limitations when measuring extremely fine or extremely coarse particles, the Bettersizer S3 Plus uses a dual lens system in combination with an obliquely incident light source. This allows for an unprecedented measurement range from 0.01 μm to 3500 μm. The system integrates as many as 96 high-sensitivity detectors that capture light scattering at an extremely wide angle. This advanced configuration ensures that even the smallest nanoparticles (from 10 nanometers) and large macroparticles (up to 3.5 millimeters) will be detected with maximum resolution and reproducibility. The obtained light scattering data is analyzed using the most advanced Mie and Fraunhofer optical models, which guarantee the highest accuracy regardless of the optical properties of the material under study.
Dynamic real-time video analysis
Laser diffraction provides spherical equivalent dimensions, but in the real world, particles are very rarely perfectly round. This is where the second and perhaps most important strength of the Bettersizer S3 Plus comes into play – the integrated dynamic image analysis system. This device is equipped with two high-resolution high-speed cameras. One camera (with 0.5X magnification) is designed to capture large particles, while the second (with 10X magnification) analyzes fine fractions in detail. These cameras are capable of capturing up to 10,000 frames per minute, which means that hundreds of thousands of individual particles are photographed and analyzed in an extremely short analysis time. Thanks to image analysis, researchers can assess not only size, but also a full range of morphological parameters: roundness, aspect ratio, elongation, compactness and surface roughness. This is especially important for identifying agglomerates, air bubbles or single oversized particles that traditional diffraction might simply attribute to the general scattering background. The ability to visually confirm the scattering results provides invaluable confidence in the quality of the measurements.
Full automation and smart dispersion
„The Bettersizer S3 Plus features an extremely powerful, integrated wet dispersion system that ensures that even the most difficult-to-disperse materials are properly prepared for measurement. The system features automatic water or other selected solvent feed, an integrated centrifugal pump with precisely adjustable speed to ensure uniform sample circulation, and a powerful ultrasonic homogenizer to effectively break up particle clumps. The entire process – from sample aspiration, ultrasonic treatment, measurement to system flushing and cleaning – is fully automated and controlled by software. This drastically reduces the likelihood of human error and significantly increases laboratory throughput.
Software and strict compliance with standards
A professional laboratory needs software that is not only powerful and intuitive, but also meets the strictest regulatory requirements. The Bettersizer S3 Plus software platform fully complies with the requirements of the US Food and Drug Administration (FDA) 21 CFR Part 11 directive. This includes multi-level user rights management, electronic signatures and comprehensive audit trails. Every step, from method creation to export of results, is recorded and protected from tampering. In addition, the device complies with ISO 13320 and ISO 13322-2 international standards, so the results are irrefutably recognized worldwide. One of the biggest advantages of the software is the Standard Operating Procedures (SOP) module. When using SOP, the laboratory technician simply selects a pre-created method, and the system automatically sets all measurement parameters, ensuring ideal repeatability between different operators.
Adaptability in modern industry
Due to its unique design and unmatched accuracy, this analyzer has become the standard choice in many high-tech industries. In the pharmaceutical industry, it is used daily to control the particle size and shape of active pharmaceutical ingredients (APIs) and excipients, which directly affects the dissolution rate of drugs. In the battery industry, the Bettersizer S3 Plus is indispensable for the analysis of cathode and anode materials for lithium-ion cells. The device is also widely used in advanced ceramics, 3D printing metal powders, pigments, dyes and specialty chemicals, where every micron is crucial to the specifications of the final product.
| Main specifications | Technical parameters |
| Measuring range (Laser) | from 0.01 μm to 3500 μm |
| Measuring range (Image) | from 2 μm to 3500 μm |
| Measurement principle | Laser diffraction + Dynamic image analysis |
| Optical system | Dual Lens, Oblique Incidence (DLOI) Technology |
| Number of detectors | 96 detectors for ultra-wide angle |
| Cameras | Two high-speed CMOS cameras (0.5X and 10X magnification) |
| Dispersion method | Fully automatic wet dispersion with ultrasound |
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