Metastatic Carcinoma 3D Model Erler-Zimmer Metastatic Carcinoma 3D Printed Model

Erler-Zimmer GmbH & Co. KG 3D model of metastatic carcinoma:

• Model code: MP2019
• Clinical history (access to CT and MRI imaging)
  • This 51-year-old woman had undergone surgery for breast carcinoma 2 years before presentation. Her chief complaint was left hemispheric ataxia for the past 2 weeks, and this was preceded by an episode of weakness on the left side. Examination revealed the presence of left spastic paralysis. There was some doubt about the diagnosis, as the velocity was suggestive of a vascular lesion. She was discharged from the hospital, but six weeks after the initial presentation she was readmitted with left-sided seizures. Spinal tap and repeat examination were unremarkable. EEG showed abnormalities in the right anterior temporal lobe. Angiography confirmed the presence of a large tear in the right brain. The patient's condition gradually deteriorated on the ward, and eventually died.
• Pathology
  • The specimen is a brain sectioned horizontally. The right hemisphere is clearly visible in the upper half, especially in the parietal region, where the gyrae are dilated and 3 cystic tumors are visible. The largest, 5 cm in diameter, is located in the right parietal region. A smaller tumor, 2 x 1.5 cm in diameter, is seen near the posterior edge of the largest tumor. The third, 1.5 cm in diameter, is located in the left parietal region. The tumors involved mainly the white matter. The wall of each lesion is composed of combed friable gray matter. At necropsy, an ulceration of the largest tumor into the right lateral fluid was noted (more clearly visible when the inferior surface is examined). A sub-falcine herniation was also seen, as well as dislocation of the basal ganglia and internal capsule. Histological examination revealed metastatic carcinoma in living sites. Other metastases were found in the liver and bone. The histology of the liver metastasis was consistent with a primary breast carcinoma in origin.
• Additional information
  • Metastatic carcinomas are the second most common central nervous system malignancy after meningiomas. They can have a variety of primary sites, including the lung, chest, liver, and kidney. Brain metastases are usually asymptomatic or cause intracranial pressure, headache, or neurological deficits. Diagnosis is based on neuroimaging and confirmed histology. They can be treated with surgery, radiotherapy, stereotactic radiosurgery, or systemic therapy. Prognosis depends on many factors, including the location and type of primary carcinoma, the number and location of metastases, and the patient's age and general health, but most patients survive for months to years.

3D models of metastatic carcinoma – Erler-Zimmer Anatomy Group

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