Erler-Zimmer GmbH & Co. KG 3D model of metastatic melanoma:
- Model code: MP2018
- Clinical history
- In 1970, a 31-year-old woman presented with severe headaches and diplopia, and had a skin lesion (diagnosed as invasive cutaneous melanoma) that she had removed from her neck 8 months earlier. Clinical examination revealed no abnormalities, and after discharge, the patient was later readmitted for persistent vomiting. His condition deteriorated and he died.
- Pathology
- This preparation shows widespread intracerebral metastases of melanoma. The inferior surface is characterized by numerous raised dark nodules up to 1.5 cm in diameter. Similar lesions are seen on the cut superior surface, where these secondary melanotic deposits are seen to be confined to the gray matter. The tumor accumulation is patchy and hemorrhaged.
- Additional information
- Of all patients with metastatic brain lesions, 10% are from cutaneous melanoma. The risk increases with age over 60 years, male gender, disease duration and more advanced tumor/metastatic stage. BRAF and NRAS mutations, CCR4 receptor expression on tumor cells and activation of the PI3K pathway are all risk factors for the development of brain metastases. 80% melanoma brain metastases are supratentorial. Headache, neurological deficits and/or seizures are common manifestations. In addition, these lesions are prone to spontaneous bleeding. Modern diagnosis is based on neuroimaging and often histology of stereotactic brain biopsy if previously undiagnosed. Treatment includes stereotactic radiotherapy (SRT), radiotherapy and/or systemic therapy with “checkpoint inhibitor immunotherapy” or targeted therapies. This has increased the median survival to 11 months in recent years.
3D models of metastatic melanoma – Erler-Zimmer Anatomy Group
More information: on the manufacturer's website or send us an inquiry!
EN 
LT 
LV