Name: Hodžkino Limfomos 3D Modelis Erler-Zimmer Hodgkin Lymphoma 3D Printed Model - Labostera
SKU: MP2062
Availability: InStock

Erler-Zimmer GmbH & Co. KG Hodgkin lymphoma 3D model:

Model Number: MP2062
Clinical history:
A 45-year-old man presented with a mass in the left supraclavicular region. The swelling had been increasing over the past 6 months. A biopsy of the mass showed Hodgkin lymphoma (HL). Ten months later he was readmitted with left shoulder pain and left arm swelling. Examination revealed generalized lymphadenopathy with significant swelling in the left supraclavicular and axillary regions. He was treated with radiotherapy and Thiotepa chemotherapy. He began vomiting. A further barium swallow showed duodenal obstruction from compression of the extramedullary lymph nodes. He continued to deteriorate and died two weeks after admission.
Pathology:
The 3D printed model shows the bifurcation of the trachea with adjacent paratracheal and peri-bronchial lymph nodes. The trachea has been dissected longitudinally and is visible from the posterior. The paratracheal lymph nodes are shiny and confluent (adherent). A similar abnormal tissue structure is seen as a uniformly pale mass on the left side of the trachea, above the aortic arch, which can be seen in transverse section as a hollow space with loops. The peri-bronchial lymph nodes are also enlarged and have carbon pigment. Circumscribed small pale areas within the lymph nodes and extranodal neoplasm are foci of necrosis. There is atheroma in the aortic wall, but it is difficult to see in the 3D model.
Additional information:
Hodgkin lymphoma (HL) is a malignant disease of lymphocytes. Its main feature is the presence of neoplastic giant cells called Reed Sternberg cells. There are 5 main subtypes, according to the World Health Organization classification of lymphomas, based on morphology, immunophenotyping and genetics. Activation of the transcription factor NF-kB is a common tumorigenesis pathway among subtypes. This promotes proliferation, reduces apoptosis and induces the expression of cytokines that recruit immune cells that engulf Reed Sternberg cells in HL.