Name: Endometriumo Karcinomos 3D Modelis Erler-Zimmer Endometrial Carcinoma 3D Printed Model - Labostera
SKU: MP2106
Availability: InStock

Erler-Zimmer GmbH & Co. KG 3D model of endometrial carcinoma:

Model: MP2106
Clinical History:
A 63-year-old woman presented with 2 months of mild lower abdominal pain and 1 week of heavy and persistent vaginal bleeding. She had been menopausal for 13 years. Following biopsy confirmation of endometrial carcinoma, radical abdominal hysterectomy and bilateral salpingo-oophorectomy are the most common procedures.
Pathology:
The specimen consists of the uterus, fallopian tubes, and ovaries. The endometrial cavity and endocervical canal are open on the anterior side. The endometrial wall is grossly abnormal, especially on the right side, and the brown polypoid tumor has invaded the myometrium and down into the cervix. Histologically, it was a well-differentiated endometrial adenocarcinoma. The left ovary, which was cut horizontally, is swollen and contains several large follicular cysts/cavities.
Additional Information:
Endometrial carcinoma is the most common gynecological malignancy in developed countries and the second most common in developing countries after cervical cancer. There are two main types of endometrial carcinoma. Endometrioid carcinoma accounts for almost 80% of all endometrial carcinomas. They usually occur early and therefore have a more favorable outcome. These tumors may arise from atypical endometrial hyperplasia. Genetic abnormalities such as mutations in the PTEN, PIK3Ca, and ARID1A genes are commonly seen in endometrioid tumors. Serous carcinoma is a less common type of endometrial carcinoma. These tumors are associated with mutations in the TP53 gene and have a worse prognosis. Endometrioid tumors usually affect women aged 55 to 65 years. Risk factors for endometrioid endometrial carcinoma include obesity, impaired glucose tolerance, infertility, and unopposed estrogen therapy (e.g., early menarche, late menopause, or exogenous sources). Serous neoplasms affect older women over the age of 65, when other risk factors include a lower body mass index and an atrophic uterus. Women with hereditary colorectal cancer syndrome of pregnancy (Lynch syndrome) have a significantly higher risk of developing endometrial cancer.