Name: Pyriform Fossa Karcinomos 3D Modelis Erler-Zimmer Carcinoma of Pyriform Fossa 3D Printed Model - Labostera
SKU: MP2051
Availability: InStock

Erler-Zimmer GmbH & Co. KG 3D model of Pyriform Fossa carcinoma:

Model Number: MP2051
Clinical history:
A 60-year-old man presented with 6 weeks of globus (a feeling of a lump in his throat) and dysphonia. On examination, he had enlarged cervical lymph nodes. Investigations revealed a laryngeal tumor. He underwent laryngectomy and cervical lymph node dissection. He made a full recovery.
Pathology:
The specimen is an amputated larynx, seen from the back. It shows an irregular ulcerated tumor originating from the left pyramidal fossa. Distortion and edema of the larynx tissues are noted. Histologically, it was a squamous cell carcinoma.
Additional information:
More than 951% of laryngeal cancers are squamous cell carcinoma (SCC). The tumor most commonly develops in the vocal cords, but can occur above or below the cords, on the epiglottis, aryepiglottic folds, or in the pyramidal sinuses. The cancer usually begins as carcinoma in situ, progressing to invasive and invasive carcinoma with continued exposure to carcinogens.
The greatest risk factors for laryngeal cancer are tobacco smoke and alcohol consumption. Human papillomavirus (HPV) infection, asbestos exposure, and radiation have also been shown to increase the incidence. Men are more affected than women. It most commonly occurs in the 50s.
Laryngeal cancer can spread by invasion into surrounding tissues, via lymph nodes, usually to the regional lymph nodes in the neck, or by hematogenous metastases, most commonly to the lungs. Common presenting symptoms include dysphonia, dysphagia, odynophagia, globus, and cough. Less common symptoms may include hemoptysis, stridor, dyspnea, and halitosis. Treatment varies depending on the stage of the disease. Smoking and alcohol cessation are important for all stages of the disease.
In early disease, laryngeal-sparing treatments may include laser therapy, microsurgery, and radiation. In later disease, treatment may include a combination of laryngectomy, radiation, and chemotherapy. HPV-associated HNSCC has a better prognosis than HPV-unassociated HNSCC. HPV vaccination programs have been introduced in several countries, including Australia and the United Kingdom, for both boys and girls, to reduce their risk of developing HNSCC.